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    Genomics. 2000 Jan 1;63(1):133-8.

    Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene.

    Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L.

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    Department of Molecular Biotechnology, University of Washington, Seattle, Washington 98195, USA.

    Abstract

    The genomic sequence of the human Jagged2 (JAG2) gene, which encodes a ligand for the Notch receptors, was determined. The 30-kb DNA sequence spanning the JAG2 gene contains 26 exons and a putative promoter region. Several potential binding sites for transcription factors, including NF-kappab, E47, E12, E2F, Ets-1, MyoD, and OCT-1, were found in the human JAG2 promoter region. The JAG2 gene was also mapped to the chromosomal region 14q32 using fluorescence in situ hybridization.

    Copyright 2000 Academic Press.

    PMID:
    10662552
    [PubMed - indexed for MEDLINE]

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