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Comput Methods Programs Biomed. 2000 Feb;61(2):99-110.

Parametric cure models of relative and cause-specific survival for grouped survival times.

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  • 1Veterans Administration Hospital and University of Louisville School of Medicine, KY 40292, USA.


With parametric cure models, we can express survival parameters (e.g. cured fraction, location and scale parameters) as functions of covariates. These models can measure survival from a specific disease process, either by examining deaths due to the cause under study (cause-specific survival), or by comparing all deaths to those in a matched control population (relative survival). We present a binomial maximum likelihood algorithm to be used for actuarial data, where follow-up times are grouped into specific intervals. Our algorithm provides simultaneous maximum likelihood estimates for all the parameters of a cure model and can be used for cause-specific or relative survival analysis with a variety of survival distributions. Current software does not provide the flexibility of this unified approach.

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