Morphine-like peptides in mammalian brain: isolati...[Proc Natl Acad Sci U S A. 1976]

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1: Proc Natl Acad Sci U S A. 1976 Jul;73(7):2515-9. Links

Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor.

Simantov R, Snyder SH.

A substance that competes for opiate receptor binding has been isolated from calf brain and identified as two pentapeptides, H-Tyr-Gly-Gly-Phe-Met-OH (methionine enkephalin) and H-Tyr-Gly-Gly-Phe-Leu-OH (leucine enkephalin), with about four times more leucine enkephalin than methionine enkephalin. Sodium and manganese effects on opiate receptor interactions show that both peptides are agonists, whereas leucine enkephalin may be a "purer" agonist than methionine enkephalin.

PMID: 1065904 [PubMed - indexed for MEDLINE]

PMCID: PMC430630

Identification of two related pentapeptides from the brain with potent opiate agonist activity.
Nature. 1975 Dec 18; 258(5536):577-80.

[Nature. 1975]
Binding to opioid receptors of enkephalin derivatives taking alpha-helical conformation and its dimer.
Int J Pept Protein Res. 1991 Oct; 38(4):378-84.

[Int J Pept Protein Res. 1991]
Characterization of an endogenous morphine-like factor(enkephalin) in mammalian brain.
Mol Pharmacol. 1976 May; 12(3):504-13.

[Mol Pharmacol. 1976]
Phylogenetic distribution of a morphine-like peptide 'enkephalin'.
Brain Res. 1976 Jul 23; 111(1):204-11.

[Brain Res. 1976]
Review[Isolation and reconstruction of cholinergic receptor proteins]
Zh Evol Biokhim Fiziol. 1976 May-Jun; 12(3):213-26.

[Zh Evol Biokhim Fiziol. 1976]
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Cited by 24 PubMed Central articles

ReviewThe transcriptional regulation of the preproenkephalin gene.
Weisinger G. Biochem J. 1995 May 1; 307 ( Pt 3):617-29.

[Biochem J. 1995]
Enkephalin-like immunoreactivity of olivocochlear nerve fibers in cochlea of guinea pig and cat.
Fex J, Altschuler RA. Proc Natl Acad Sci U S A. 1981 Feb; 78(2):1255-9.

[Proc Natl Acad Sci U S A. 1981]
Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.
Stinus L, Koob GF, Ling N, Bloom FE, Le Moal M. Proc Natl Acad Sci U S A. 1980 Apr; 77(4):2323-7.

[Proc Natl Acad Sci U S A. 1980]
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