J Mol Evol. 2000 Jan;50(1):98-102.

Testing the extent of sequence similarity among viroids, satellite RNAs, and hepatitis delta virus.

Jenkins GM, Woelk CH, Rambaut A, Holmes EC.

Abstract

A Monte Carlo method was used to test the extent of sequence similarity among viroids, satellite RNAs, and hepatitis delta virus. This analysis revealed that there is insufficient sequence similarity among these pathogens to support the hypothesis that they have a common evolutionary origin. Furthermore, while definite patterns of sequence similarity were observed among some viroids, there was a clear lack of overall similarity, indicating that a monophyletic origin for even this group cannot be reliably supported from sequence data alone.

PMID:: 10654264; [PubMed - indexed for MEDLINE]

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