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Trends Cell Biol. 2000 Feb;10(2):60-7.

Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors.

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  • 1Service de Biochimie et Génétique Moléculaire, CEA/Saclay, Gif-sur-Yvette, France.


ARF proteins are important regulators of membrane dynamics and protein transport within the eukaryotic cell. The Sec7 domain is approximately 200 amino acids in size and stimulates guanine-nucleotide exchange on members of the ARF class of small GTPases. The members of one subclass of Sec7-domain proteins are direct targets of the secretion-inhibiting drug brefeldin A, which blocks the exchange reaction by trapping a reaction intermediate in an inactive, abortive complex. A separate subclass of Sec7-domain proteins is involved in signal transduction and possess a domain that mediates membrane binding in response to extracellular signals.

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