Trends Endocrinol Metab. 2000 Jan-Feb;11(1):11-5.

The beta cell in autoimmune diabetes: many mechanisms and pathways of loss.

Kay TW, Thomas HE, Harrison LC, Allison J.

Source

Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia.

Abstract

Death of pancreatic beta cells is the final step in the pathogenesis of type 1 diabetes before it becomes clinically apparent. Applying recent basic research about how cells die to the clinical problem of diabetes is a current opportunity and challenge. To date, perforin is the only factor definitely implicated in beta-cell killing in the non-obese diabetic (NOD) mouse model, although some perforin-deficient NOD mice develop diabetes. Our results suggest that other factors that cause beta-cell death remain to be identified.

PMID:: 10652500; [PubMed - indexed for MEDLINE]

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