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Genes Dev. 2000 Jan 15;14(2):147-51.

Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis.

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  • 1Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210 USA. kaestner@mail.med.upenn.edu


Organogenesis requires coordination between developmental specific regulators and genes governing cell proliferation. Here we show that Drosophila prospero encodes a critical regulator of the transition from mitotically active cells to terminal differentiated neurons. Loss of pros results in aberrant expression of multiple cell-cycle regulatory genes and ectopic mitotic activity. In contrast, ectopic pros expression causes transcriptional suppression of multiple cell-cycle regulatory genes and premature termination of cell division. pros activity, hence, provides a critical regulatory link between neuronal lineage development and transcriptional regulation of cell cycle regulatory genes.

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