Send to:

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 2000 Feb;3(2):164-9.

High-resolution mapping of iso-orientation columns by fMRI.

Author information

  • 1Center for Magnetic Resonance Research, University of Minnesota Medical School, 2021 6th Street S.E., Minneapolis, Minnesota 55455, USA.


Blood-oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is an important tool for localizing brain functions in vivo. However, the ability of BOLD fMRI to map cortical columnar structures is highly controversial, as the ultimate functional specificity of BOLD remains unknown. Here we report a biphasic BOLD response to visual stimulation in the primary visual cortex of cats. In functional imaging, the initial BOLD signal decrease accurately labeled individual iso-orientation columns. In contrast, the delayed positive BOLD changes indicated the pattern of overall activation in the visual cortex, but were less suited to discriminate active from inactive columns.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk