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FEBS Lett. 2000 Jan 21;466(1):143-7.

The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7.

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  • 1Department of Molecular Cell Biology, Max-Planck-Institute for Physiological and Clinical Research, Parkstr. 1, 61231, Bad Nauheim, Germany.


Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation.

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