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Cytogenet Cell Genet. 1999;87(1-2):19-21.

cDNA cloning of human muskelin and localisation of the muskelin (MKLN1) gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH.

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  • 1MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, UK.


Muskelin is a novel intracellular protein, identified in mouse cells, that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin-1. We report that human muskelin is 98% identical with mouse muskelin at the amino acid level. The human muskelin gene is located at 7q32. The mouse muskelin gene maps syntenically at chromosome 6 B1/B2.

Copyright 1999 S. Karger AG, Basel

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