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Trends Microbiol. 2000 Jan;8(1):17-23.

Serotype-converting bacteriophages and O-antigen modification in Shigella flexneri.

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  • 1Divn of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, ACT, 0200, Australia.


O-antigen modification (serotype conversion) in Shigella flexneri, which is an important virulence determinant, is conferred by temperate bacteriophages. Several serotype-converting phages have been isolated and preliminary characterization has identified the genes involved in O-antigen modification, and has also provided insight into the molecular biology of these phages.

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