This study evaluated the sealing ability of fast and regular set Super-EBA with different powder-to-liquid ratios as a root-end filling material. Fifty extracted maxillary central incisors were uniformly cleaned and shaped using a crown-down technique with Gates-Glidden drills and Profile series 29.04 taper rotary instruments. After root-end resection and ultrasonic preparation, 48 root sections were randomly assigned to 4 groups of 12 teeth each and filled with a thick or thin mix of fast or regular set Super-EBA. Fast and regular set Super-EBA were mixed to a thick (1 scoop powder:1 drop liquid) or a thin (1 scoop powder:2 drops liquid) consistency. Positive and negative controls were used. Microleakage was assessed at 24 h, 72 h, 1 wk, 2 wk, 4 wk, 6 wk, and 8 wk using a fluid filtration system. There were no significant differences in the microleakage measured for any group at any of the time points evaluated. These results suggest that either fast or regular set Super-EBA mixed to various consistencies may be acceptable for root-end filling.