Send to:

Choose Destination
See comment in PubMed Commons below
Clin Nutr. 1999 Dec;18(6):371-4.

Oral supplements as adjunctive treatment to nutritional counseling in malnourished HIV-infected patients: randomized controlled trial.

Author information

  • 1Klinik I für Innere Medizin, University of Cologne, Cologne, Germany.



To compare nutritional counseling with and without oral supplements in HIV-infected patients with recent weight loss.


Randomized non-blinded controlled trial, stratified for change in antiretroviral treatment at baseline.


HIV-infected patients with recent weight loss (> 5% of total, and >3% in the last month).


Nutritional counseling to increase dietary intake by 600 kcal/day over 8 weeks; in group A (n=24) by normal food, and in group B (n=26) by a range of fortified drink supplements with a calorific value of 0.6 to 1.5 kcal/ml.


Body composition by bioelectrical impedance analysis, dietary intake by 24 h recall.


Fat free mass increased from baseline to week 8 (P<0.05) with no difference between groups A and B (P=0.97). Body cell mass and weight gain were not significant and equal between groups. Assessed at weeks 2 and 4, group B patients consumed 11 +/- 6 kcal/kg as supplements, and their total energy intake was 6 kcal/kg higher than in group A (P<0.01). Total energy intake was not different between groups at weeks 6 and 8.


Nutritional counseling and oral supplements are both feasible methods to restore food energy intake in malnourished HIV-infected patients. Although normal food intake is partially replaced, oral supplements may improve the adherence to a weight gain regimen.

Copyright 1999 Harcourt Publishers Ltd.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk