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J Allergy Clin Immunol. 2000 Jan;105(1 Pt 1):54-7.

Minimal persistent inflammation is also present in patients with seasonal allergic rhinitis.

Author information

  • 1Allergy Section, Koellider Hospital, Turin, Italy.

Abstract

BACKGROUND:

The allergic reaction is characterized by an inflammatory response, which is correlated to the allergen exposure, and is detectable in mite allergic patients, even when symptoms are absent.

OBJECTIVE:

The study was aimed at assessing the presence of inflammation in patients with pollen allergy during a long observation period.

METHODS:

Six patients, sensitized only to Betula alba, were enrolled. Evaluated parameters were (1) nasal symptoms, (2) inflammatory markers (ie, neutrophil and eosinophil number and intercellular adhesion molecule-1 expression on nasal epithelial cells), and (3) pollen count. Patients were examined during the pollen season every 4 days for 40 days and were observed 3 times after the pollen season.

RESULTS:

A significant inflammatory reaction was evident throughout the pollen season, even during the days with a low pollen count and low or absent symptoms.

CONCLUSIONS:

The results of this study indicate that the global therapeutic strategy for allergic rhinitis should be revised and targeted to inflammatory phenomena rather than to symptoms alone.

PMID:
10629452
[PubMed - indexed for MEDLINE]
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