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Arch Pathol Lab Med. 2000 Jan;124(1):127-9.

Massive noninflammatory periportal liver necrosis following concentrated acetic acid ingestion.

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  • 1Departments of Emergency and Critical Care Medicine, Kitasato University, School of Medicine, Sagamihara, Kanagawa, Japan.


In a fatal occurrence of massive liver necrosis following ingestion of concentrated (90%) acetic acid, the patient showed evidence of hemolysis, disseminated intravascular coagulation, and liver dysfunction at only 45 minutes after exposure. With refractory to vigorous supportive care, the patient s condition deteriorated until death occurred 39 hours after ingestion, despite some improvement of coagulopathy. Autopsy revealed corrosive injuries in the upper gastrointestinal tract and massive hepatic necrosis in a periportal distribution without significant inflammation. A direct effect of the noxious agent on hepatocytes involving the portal circulation is suggested.

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