Analysis of X-ray-induced aberrations in human chromosome 5 using high-resolution multicolour banding FISH (mBAND)

Chromosome Res. 1999;7(8):625-33. doi: 10.1023/a:1009284018942.

Abstract

Peripheral lymphocytes were exposed to 4 Gy X-rays and aberrations were analysed in human chromosome 5 using high-resolution multicolour banding fluorescence in-situ hybridization (mBAND). This method is suited to detect simple and complex aberrations including peri- and paracentric inversions and exchanges between both chromosomes 5. Additionally, breakpoints carr be assigned to specific regions in chromosome 5. Quantitative relationships of induced aberration types are discussed.

MeSH terms

  • Chromosome Aberrations*
  • Chromosome Banding
  • Chromosomes, Human, Pair 5*
  • Humans
  • In Situ Hybridization, Fluorescence
  • In Vitro Techniques
  • Male
  • X-Rays