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Hematol Oncol Clin North Am. 1999 Dec;13(6):1281-94.

Heavy-chain diseases.

Author information

  • 1Department of Immuno-Hematology, Hôpital Saint-Louis, Paris, France. immuno-hem@chu-stlouis.fr

Abstract

This review underscores the diversity of the structural and genetic abnormalities of HCD proteins and of the clinicopathologic features of the underlying lymphoproliferative disorders. Cells producing HCD may, however, all derive from a common normal precursor, which could be a rare B cell in the process of immunoglobulin gene somatic mutation within the germinal center.

PMID:
10626151
[PubMed - indexed for MEDLINE]
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