Send to:

Choose Destination
See comment in PubMed Commons below
Biol Psychiatry. 1999 Dec 15;46(12):1707-8.

Mania associated with St. John's wort.

Author information

  • 1Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, USA.



St. John's wort, the popular herbal remedy touted as an antidepressant, is generally thought to be benign, with few reported side effects. Given its possible efficacy as an antidepressant, evaluation of its propensity to cause affective switching should be evaluated.


This report presents two cases of mania temporally associated with the use of St. John's wort (hypericum).


As with other antidepressant agents, St. John's wort may precipitate hypomania, mania, or an increased cycling of mood states, particularly in patients with occult bipolar disorder.


Because the majority of people who take this popular over-the-counter preparation do so without formal psychiatric evaluations, risk of hypericum-induced mania may be significant. Physicians should screen patients for a history of hypomania or mania before recommending use of St. John's wort for depression.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk