Biochem Biophys Res Commun. 2000 Jan 7;267(1):456-61.

Identification of tyrosine hydroxylase as an autoantigen in autoimmune polyendocrine syndrome type I.

Hedstrand H, Ekwall O, Haavik J, Landgren E, Betterle C, Perheentupa J, Gustafsson J, Husebye E, Rorsman F, Kämpe O.

Department of Medical Sciences, University Hospital, Uppsala, Sweden. hakan.hedstrand@medsci.uu.se

Abstract

Patients with the autosomal recessively inherited autoimmune polyendocrine syndrome type I (APS I) have autoantibodies directed against several endocrine and nonendocrine organs. In this study a new autoantigen related to this syndrome, tyrosine hydroxylase, was identified in sera from patients with alopecia areata through immunoscreening of a scalp cDNA library. Immunoreactivity against in vitro expressed tyrosine hydroxylase was found in 41 (44%) of the 94 APS I patients studied and this reactivity correlated with the presence of alopecia areata (P = 0.02). These findings further stress the importance of enzymes involved in neurotransmitter biosynthesis as important immune targets in APS I. Copyright 2000 Academic Press.

PMID: 10623641 [PubMed - indexed for MEDLINE]

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Identification of tyrosine hydroxylase as an autoantigen in autoimmune polyendocrine syndrome type I.

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