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Identification of tyrosine hydroxylase as an autoantigen in autoimmune polyendocrine syndrome type I.
Department of Medical Sciences, University Hospital, Uppsala, Sweden. hakan.hedstrand@medsci.uu.se
Patients with the autosomal recessively inherited autoimmune polyendocrine syndrome type I (APS I) have autoantibodies directed against several endocrine and nonendocrine organs. In this study a new autoantigen related to this syndrome, tyrosine hydroxylase, was identified in sera from patients with alopecia areata through immunoscreening of a scalp cDNA library. Immunoreactivity against in vitro expressed tyrosine hydroxylase was found in 41 (44%) of the 94 APS I patients studied and this reactivity correlated with the presence of alopecia areata (P = 0.02). These findings further stress the importance of enzymes involved in neurotransmitter biosynthesis as important immune targets in APS I. Copyright 2000 Academic Press.
PMID: 10623641 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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Absence of autoantibodies connected to autoimmune polyendocrine syndrome type I and II and Addison's disease in girls and women with Turner syndrome.
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[J Negat Results Biomed. 2007]
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[Biochem Biophys Res Commun. 2008]
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Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1.
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[Proc Natl Acad Sci U S A. 2007]
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