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    Lancet. 2000 Jan 1;355(9197):39-40.

    Hypocretin (orexin) deficiency in human narcolepsy.

    Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E.

    Abstract

    Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models. Hypocretin was undetectable in seven out of nine people with narcolepsy, indicating abnormal hypocretin transmission.

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    PMID:
    10615891
    [PubMed - indexed for MEDLINE]

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