Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2000 Jan 7;287(5450):125-8.

Modulation of brain reward circuitry by leptin.

Author information

  • 1Center for Studies in Behavioural Neurobiology, Concordia University, MontrĂ©al, QC, H3G 1M8, Canada.

Erratum in

  • Science 2000 Mar 17;287(5460):1931.

Abstract

Leptin, a hormone secreted by fat cells, suppresses food intake and promotes weight loss. To assess the action of this hormone on brain reward circuitry, changes in the rewarding effect of lateral hypothalamic stimulation were measured after leptin administration. At five stimulation sites near the fornix, the effectiveness of the rewarding electrical stimulation was enhanced by chronic food restriction and attenuated by intracerebroventricular infusion of leptin. In contrast, the rewarding effect of stimulating neighboring sites was insensitive to chronic food restriction and was enhanced by leptin in three of four cases. These opposing effects of leptin may mirror complementary changes in the rewarding effects of feeding and of competing behaviors.

PMID:
10615045
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk