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J Cell Biol. 1999 Dec 27;147(7):1371-8.

Mitotic regulators govern progress through steps in the centrosome duplication cycle.

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  • 1Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California-San Francisco, San Francisco, California 94143-0448, USA.


Centrosome duplication is marked by discrete changes in centriole structure that occur in lockstep with cell cycle transitions. We show that mitotic regulators govern steps in centriole replication in Drosophila embryos. Cdc25(string), the expression of which initiates mitosis, is required for completion of daughter centriole assembly. Cdc20(fizzy), which is required for the metaphase-anaphase transition, is required for timely disengagement of mother and daughter centrioles. Stabilization of mitotic cyclins, which prevents exit from mitosis, blocks assembly of new daughter centrioles. Common regulation of the nuclear and centrosome cycles by mitotic regulators may ensure precise duplication of the centrosome.

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