Reprod Fertil Dev. 1998;10(7-8):593-8.

Influence of epigenetic changes during oocyte growth on nuclear reprogramming after nuclear transfer.

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Nodai Research Institute, Tokyo University of Agriculture, Japan. tomohiro@nodai.ac.jp

Abstract

Genomic imprinting is the epigenetic mechanism that distinguishes whether the loci that are inherited from the maternal or paternal genome lead to parent-specific gene expression. The mechanism also regulates development in mammalian embryos. Genomic imprinting is established after implantation according to the specific markers that are imposed on the genome during gametogenesis; the allele-specific gene expression is then maintained throughout embryogenesis. The genomic imprinting markers are erased and renewed on an own-sex basis only in cells that differentiate into germline cells. This report shows that the epigenetic modifications that occur during oogenesis perform the crucial function of establishing the allele-specific expression of imprinted genes, and also suggests that the epigenetic DNA modification is related to the reprogramming and aberrant development seen in manipulated embryos.

PMID:: 10612465; [PubMed - indexed for MEDLINE]

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