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Mol Cell Biol. 2000 Jan;20(2):556-62.

The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc.

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  • 1Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014, USA.

Abstract

The c-Myc protein functions as a transcription factor to facilitate oncogenic transformation; however, the biochemical and genetic pathways leading to transformation remain undefined. We demonstrate here that the recently described c-Myc cofactor TRRAP recruits histone acetylase activity, which is catalyzed by the human GCN5 protein. Since c-Myc function is inhibited by recruitment of histone deacetylase activity through Mad family proteins, these opposing biochemical activities are likely to be responsible for the antagonistic biological effects of c-Myc and Mad on target genes and ultimately on cellular transformation.

PMID:
10611234
[PubMed - indexed for MEDLINE]
PMCID:
PMC85131
Free PMC Article

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