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Proc Natl Acad Sci U S A. 1976 Jan;73(1):208-12.

Purkinje cell degeneration, a new neurological mutation in the mouse.

Abstract

A new autosomal recessive mouse mutation, Purkinje cell degeneration (pcd), is described. Mutants exhibit a moderate ataxia beginning at 3 to 4 weeks of age. The ataxia results from postnatal degeneration of virtually all cerebellar Purkinje cells beginning around 15 to 18 days of age and progressing rapidly over the next 2 weeks. In addition to the cerebellar disease there is slow progressive degeneration in the retina (photoreceptor cells) and olfactory bulb. Also, adult males have abnormal sperm.

PMID:
1061118
[PubMed - indexed for MEDLINE]
PMCID:
PMC335870
Free PMC Article
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