J Asthma. 1999 Dec;36(8):631-44.

Gastroesophageal reflux and asthma: are they related?

Source

Division of Respirology, University of Calgary Medical School and the Calgary Asthma Program, Alberta, Canada. sfield@ucalgary.ca

Abstract

The relationship between asthma and gastroesophageal reflux (GER) is controversial. This paper reviews the evidence for an association between them, the effect of asthma on GER, and the effects of GER and antireflux therapy on asthma. The association between the two conditions seems firm but studies of the effects of GER on asthma and asthma on GER are contradictory. Critical review suggests that GER affects asthma symptoms but not pulmonary function. Antireflux therapy improves asthma symptoms and reduces medication requirements but does not improve pulmonary function. The paradox of GER causing asthma symptoms but not changing pulmonary function may be explained by its increasing minute ventilation rather than triggering bronchospasm.

PMID:: 10609618; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Bronchodilator Agents

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Related citations

Review Gastroesophageal reflux and asthma: can the paradox be explained? [Can Respir J. 2000]
Review Gastroesophageal reflux and asthma: can the paradox be explained?
Field SK. Can Respir J. 2000 Mar-Apr; 7(2):167-76.
Review The effects of antireflux surgery on asthmatics with gastroesophageal reflux. [Chest. 1999]
Review The effects of antireflux surgery on asthmatics with gastroesophageal reflux.
Field SK, Gelfand GA, McFadden SD. Chest. 1999 Sep; 116(3):766-74.
Asthmatics with gastroesophageal reflux: long term results of a randomized trial of medical and surgical antireflux therapies. [Am J Gastroenterol. 2003]
Asthmatics with gastroesophageal reflux: long term results of a randomized trial of medical and surgical antireflux therapies.
Sontag SJ, O'Connell S, Khandelwal S, Greenlee H, Schnell T, Nemchausky B, Chejfec G, Miller T, Seidel J, Sonnenberg A. Am J Gastroenterol. 2003 May; 98(5):987-99.
Review Gastroesophageal reflux and asthma. [Am J Med. 1997]
Review Gastroesophageal reflux and asthma.
Sontag SJ. Am J Med. 1997 Nov 24; 103(5A):84S-90S.
Does medical antireflux therapy improve asthma in asthmatics with gastroesophageal reflux?: a critical review of the literature. [Chest. 1998]
Does medical antireflux therapy improve asthma in asthmatics with gastroesophageal reflux?: a critical review of the literature.
Field SK, Sutherland LR. Chest. 1998 Jul; 114(1):275-83.

See reviews... See all...

Cited by 3 PubMed Central articles

Gastroesophageal reflux in children with refractory asthma. [Oman Med J. 2010]
Gastroesophageal reflux in children with refractory asthma.
Deeb AS, Al-Hakeem A, Dib GS. Oman Med J. 2010 Jul; 25(3):218-21.
Review The association between gastro-oesophageal reflux disease and asthma: a systematic review. [Gut. 2007]
Review The association between gastro-oesophageal reflux disease and asthma: a systematic review.
Havemann BD, Henderson CA, El-Serag HB. Gut. 2007 Dec; 56(12):1654-64. Epub 2007 Aug 6.
The utility of ambulatory pH monitoring in patients presenting with chronic cough and asthma. [Can J Gastroenterol. 2007]
The utility of ambulatory pH monitoring in patients presenting with chronic cough and asthma.
Alhabib KF, Vedal S, Champion P, Fitzgerald JM. Can J Gastroenterol. 2007 Mar; 21(3):159-63.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Gastroesophageal reflux and asthma: are they related?
Gastroesophageal reflux and asthma: are they related?
J Asthma. 1999 Dec ;36(8):631-44.

PubMed
Skin as an endocrine organ: implications for its function.
Skin as an endocrine organ: implications for its function.
Drug Discov Today Dis Mech. 2008 Jun 1;5(2):137-144.

PubMed
Elevated serum C-reactive protein concentration in Bosnian patients with probabl...
Elevated serum C-reactive protein concentration in Bosnian patients with probable Alzheimer's disease.
J Alzheimers Dis. 2007 Sep ;12(2):151-6.

PubMed
Diabetes mellitus-associated atherosclerosis: mechanisms involved and potential ...
Diabetes mellitus-associated atherosclerosis: mechanisms involved and potential for pharmacological invention.
Am J Cardiovasc Drugs. 2006 ;6(1):15-40.

PubMed
Components associated with adequacy of help for consumers with severe mental dis...
Components associated with adequacy of help for consumers with severe mental disorders.
Adm Policy Ment Health. 2010 Nov ;37(6):497-508.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: