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Curr Opin Struct Biol. 1999 Dec;9(6):663-9.

Structure and electron transfer mechanism of pyruvate:ferredoxin oxidoreductase.

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  • 1Laboratoire de Cristallographie et de Cristallogenèse des Protéines, Institut de Biologie Structurale J-P Ebel (CEA, CNRS), Grenoble, 38027, France. charon@ibs.fr

Abstract

The first crystal structure of pyruvate:ferredoxin oxidoreductase to be determined has provided significant new information on its structural organization and redox chemistry. Spectroscopic analyses of a radical reaction intermediate have shed more light on its thiamin-based mechanism of catalysis. Different approaches have been used to study the interaction between the enzyme and ferredoxin, its redox partner.

PMID:
10607667
[PubMed - indexed for MEDLINE]
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