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Curr Opin Genet Dev. 1999 Dec;9(6):657-63.

Interspersed repeats and other mementos of transposable elements in mammalian genomes.

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  • 1Axys Pharmaceuticals, Inc., La Jolla, 92037-1029, USA.


The bulk of the human genome is ultimately derived from transposable elements. Observations in the past year lead to some new and surprising ideas on functions and consequences of these elements and their remnants in our genome. The many new examples of human genes derived from single transposon insertions highlight the large contribution of selfish DNA to genomic evolution.

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