Format

Send to:

Choose Destination
See comment in PubMed Commons below
Immunogenetics. 1999 Nov;50(3-4):201-12.

Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism.

Author information

  • 1Epimmune Inc., 5820 Nancy Ridge Drive, Suite 100, San Diego, CA 92121, USA.

Abstract

Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44- supertype alleles, and biological data demonstrating their immunological relevance, we analyze the frequency at which these supertype alleles are expressed in various ethnicities and discuss the relevance of those observations to vaccine development. Next, the existence of five new supertypes (A1, A24, B27, B58, and B62) is reported. As a result, it is possible to account for the predominance of all known HLA class I with only nine main functional binding specificities. The practical implications of this finding, as well as its relevance to understanding the functional implication of MHC polymorphism in humans, are discussed.

PMID:
10602880
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk