Oncol Rep. 2000 Jan-Feb;7(1):169-70.

Inverse association of prostate cancer and non-steroidal anti-inflammatory drugs (NSAIDs): results of a case-control study.

Source

The Ohio State University, Comprehensive Cancer Center, Columbus, OH 43210-1240, USA.

Abstract

We examined the association of prostate cancer and non-steroidal anti-inflammatory drugs (NSAIDs) in a case control study of 417 prostate cancer patients and 420 group-matched control subjects. Regular daily use of over the counter NSAIDs, ibuprofen or aspirin, was associated with a 66% reduction in prostate cancer risk (odds ratio = 0.34, 95% confidence interval = 0.23-0.58, p<0.01). The risk of prostate cancer was also significantly reduced in men who reported taking prescription NSAIDs (odds ratio = 0.35, 95% confidence interval = 0.15-0.84, p<0.05). These results suggest that NSAIDs may have value in the chemoprevention of prostate cancer.

PMID:: 10601612; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Anti-Inflammatory Agents, Non-Steroidal

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