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Curr Opin Cell Biol. 1999 Dec;11(6):732-6.

How do small GTPase signal transduction pathways regulate cell cycle entry?

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  • Chester Beatty Laboratories, Cancer Research Campaign Centre for Cell and Molecular Biology, Institute of Cancer Research, London, SW3 6JB, UK. chrism@icr.ac.uk.


A variety of studies have shown that activation of the cell cycle machinery requires the participation of multiple signalling pathways. These pathways include Ras-dependent effectors such as the extracellular-signal related kinases, otherwise known as mitogen-activated protein kinases (ERKs, MAPKs), phosphatidylinositol 3 (PI3)-kinase and p21Ral pathways, as well as other signalling pathways regulated by the small GTPases p21Rho, p21Rac and p21Cdc42.

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