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    Clin Chem Lab Med. 1999 Sep;37(9):913-7.

    Autoantibodies against oxidized LDL in the first phase of life. Low density lipoproteins.

    Steinerová A, Racek J, Stozický F, Tatzber F, Lapin A.

    MEDICA Centrum Pilsen, Czech Republic.

    The study presents a comparison of data concerning lipid metabolism and lipid oxidation (oxidative stress) in children at the time of their birth and 3 months later, as well as of their mothers at the time of delivery, compared to a control group of non-pregnant women of the same age. The data confirm that labour represents an oxidative stress for both mother and child; it is expressed as a significant increase of malondialdehyde concentration in mothers immediately after delivery in comparison with non-pregnant women (p<0.001). Its concentration in newborns was even higher than in their mothers (p<0.005). Concentration of antibodies against oxidized LDL (oxLDLAb) was comparable in mothers and newborns due to their transplacental transport. During the first three months of life these autoantibodies increased almost two-fold. The importance of this unique observation is discussed with respect to possible early atherogenesis.

    PMID: 10596958 [PubMed - indexed for MEDLINE]

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