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Nature. 1999 Dec 2;402(6761):483-7.

Synexpression groups in eukaryotes.

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  • 1Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.


In 1960, Jacob and Monod described the bacterial operon, a cluster of functionally interacting genes whose expression is tightly coordinated. Global expression analysis has shown that the highly coordinate expression of genes functioning in common processes is also a widespread phenomenon in eukaryotes. These sets of co-regulated genes, or 'synexpression groups', show a striking parallel to the operon, and may be a key determinant facilitating evolutionary change leading to animal diversity.

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