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Proc Assoc Am Physicians. 1999 Nov-Dec;111(6):547-59.

Asthma therapy with agents preventing leukotriene synthesis or action.

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  • 1Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.


Elucidation of the biochemistry of leukotriene production and the pharmacology of its actions has led to the development of a number of therapeutic agents shown to be of value in the treatment of asthma. These agents either prevent the synthesis of the leukotrienes, by preventing the action of the 5-lipoxygenase-activating protein or the catalytic action of the 5-lipoxygenase, or by inhibiting the action of leukotrienes at the CysLT1 receptor. Numerous clinical trials in exercise-induced asthma, allergen-induced asthma, aspirin-induced asthma, and spontaneously occurring asthmatic episodes have indicated that these agents are safe and effective asthma treatments.

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