Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Proc Assoc Am Physicians. 1999 Nov-Dec;111(6):547-59.

Asthma therapy with agents preventing leukotriene synthesis or action.

Author information

  • Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Abstract

Elucidation of the biochemistry of leukotriene production and the pharmacology of its actions has led to the development of a number of therapeutic agents shown to be of value in the treatment of asthma. These agents either prevent the synthesis of the leukotrienes, by preventing the action of the 5-lipoxygenase-activating protein or the catalytic action of the 5-lipoxygenase, or by inhibiting the action of leukotrienes at the CysLT1 receptor. Numerous clinical trials in exercise-induced asthma, allergen-induced asthma, aspirin-induced asthma, and spontaneously occurring asthmatic episodes have indicated that these agents are safe and effective asthma treatments.

PMID:
10591083
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk