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Biosci Rep. 1999 Aug;19(4):261-71.

Adherence of Plasmodium falciparum-infected erythrocytes to chondroitin 4-sulfate.

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  • 1Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA. gowda@bc.georgetown.edu

Abstract

Adherence of Plasmodium falciparum-infected erythrocytes (PRBCs) to the microvascular endothelium of specific organs and consequent sequestration is believed to be responsible for the development of malaria pathology. A number of studies have shown that cell adhesion molecules expressed on the surface of endothelial cells mediate the adherence. Recent studies indicate that a subpopulation of PRBCs adhere to chondroitin 4-sulfate (C4S). This adhesion can be effectively inhibited by C4S oligosaccharides. In pregnant women, the placenta specifically selects C4S-adherent PRBCs, and thus these phenotypes multiply and sequester in the intervillous spaces. Over successive pregnancies, women develop a protective humoral response to the C4S-adhesion phenotype. Disruption of C4S-mediated PRBCs adhesion using either a C4S oligosaccharide mimetic or an antiC4S-adhesion vaccine can be an efficient strategy for the treatment of malaria caused by C4S-adherent P. falciparum.

PMID:
10589991
[PubMed - indexed for MEDLINE]
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