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Ned Tijdschr Geneeskd. 1999 Nov 13;143(46):2305-7.

[Universal influenza vaccine still far in the future].

[Article in Dutch]

Author information

  • 1Nationaal Influenza Centrum van de Wereldgezondheidsorganisatie, Erasmus Universiteit, afd. Virologie, Rotterdam.


Recent publications suggest that a universal vaccine against human influenza might be feasible. The vaccine would be based on the M2 protein of influenza A viruses. As yet application of such a universal vaccine seems to be far away, however, since so far only pre-clinical data in a mouse model have been generated. Furthermore, the M2 protein is only present in influenza A viruses and is known to be a minor viral antigen. In addition it may become more variable when it is exposed to immunity in the vaccinated population.

[PubMed - indexed for MEDLINE]
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