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Am J Psychiatry. 1999 Dec;156(12):1996-7.

Why does postpsychotic IQ decline in childhood-onset schizophrenia?

Author information

  • 1Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA.

Abstract

OBJECTIVE:

The authors' goal was to examine whether the postpsychotic decline in full scale IQ during adolescence for patients with childhood-onset schizophrenia is due to a dementing process or simply failure to acquire new information and skills.

METHOD:

Linear regression was used to determine the rate of change for scaled and raw scores on subtests of 31 patients with childhood-onset schizophrenia. The resulting slopes were examined and related to changes in the patients' brains determined by magnetic resonance imaging.

RESULTS:

Three postpsychotic subtest scaled scores declined significantly: picture arrangement, information, and block design. In contrast, there was no decline in the non-age-corrected (raw) scores for any subtest. A significant correlation was found between decrease in hippocampal volume and a smaller increase in raw score on the information subtest.

CONCLUSIONS:

The decline during adolescence in the full-scale IQ of patients with childhood-onset schizophrenia does not reflect dementia but, rather, an inability to acquire new information and abilities.

PMID:
10588420
[PubMed - indexed for MEDLINE]
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