J Clin Pharmacol. 1999 Dec;39(12):1203-11.

The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions.

Source

Quintiles, Inc., Kansas City, Missouri, USA.

Abstract

P-glycoprotein (PGP) is well known because of its contribution to multiple-drug resistance during anticancer treatment. More recent work indicates that PGP mediates the transcellular transport of many drugs in addition to anticancer compounds. Because of this reason, its potential role in clinically significant drug-drug interactions has just begun to be realized. This article provides an overview of published in vitro, in situ, and in vivo drug-drug interaction results that are related to PGP transport so that the awareness of the scientific community can be heightened. In addition, several recommendations are made to take full advantage of the recently published data.

PMID:: 10586385; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Drug Reactions - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. [J Pharmacol Exp Ther. 2002]
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.
Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG. J Pharmacol Exp Ther. 2002 Oct; 303(1):323-32.
Review Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. [Mol Carcinog. 1995]
Review Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.
Wacher VJ, Wu CY, Benet LZ. Mol Carcinog. 1995 Jul; 13(3):129-34.
Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. [Pharm Res. 1999]
Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.
Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, et al. Pharm Res. 1999 Mar; 16(3):408-14.
P-Glycoprotein in clinical cardiology. [Circulation. 1999]
P-Glycoprotein in clinical cardiology.
Rodriguez I, Abernethy DR, Woosley RL. Circulation. 1999 Feb 2; 99(4):472-4.
Review The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein. [Clin Pharmacokinet. 2001]
Review The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein.
Zhang Y, Benet LZ. Clin Pharmacokinet. 2001; 40(3):159-68.

See reviews... See all...

Cited by 9 PubMed Central articles

Review Efflux transporters- and cytochrome P-450-mediated interactions between drugs of abuse and antiretrovirals. [Life Sci. 2011]
Review Efflux transporters- and cytochrome P-450-mediated interactions between drugs of abuse and antiretrovirals.
Pal D, Kwatra D, Minocha M, Paturi DK, Budda B, Mitra AK. Life Sci. 2011 May 23; 88(21-22):959-71. Epub 2010 Nov 1.
The pharmacological management of migraine, part 1: overview and abortive therapy. [P T. 2008]
The pharmacological management of migraine, part 1: overview and abortive therapy.
Demaagd G. P T. 2008 Jul; 33(7):404-16.
Interactions of grapefruit juice and cardiovascular medications: A potential risk of toxicity. [Exp Clin Cardiol. 2003]
Interactions of grapefruit juice and cardiovascular medications: A potential risk of toxicity.
Lim GE, Li T, Buttar HS. Exp Clin Cardiol. 2003 Summer; 8(2):99-107.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions.
The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions.
J Clin Pharmacol. 1999 Dec ;39(12):1203-11.

PubMed
Cerebellar influences on autonomic mechanisms. An experimental study in the cat ...
Cerebellar influences on autonomic mechanisms. An experimental study in the cat with special reference to the fastigial nucleus.
Acta Physiol Scand Suppl. 1975 ;425:1-42.

PubMed
Why do Schwann cells survive in the absence of axons?
Why do Schwann cells survive in the absence of axons?
Ann N Y Acad Sci. 1999 Sep 14 ;883:109-15.

PubMed
Dose-dependent effect of folic acid on the prevention of orofacial clefts.
Dose-dependent effect of folic acid on the prevention of orofacial clefts.
Pediatrics. 1999 Dec ;104(6):e66.

PubMed
Organization and sequence of the gene for the human mitochondrial dicarboxylate ...
Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family.
Biochem J. 1999 Dec 15 ;344 Pt 3:953-60.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 9 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information