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Nat Med. 1999 Dec;5(12):1359-64.

Clinical applications of angiogenic growth factors and their inhibitors.

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  • 1Department of Molecular Oncology Genentech DNA Way South San Francisco, California 94080, USA.


Promoting the formation of new collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis) is a an exciting frontier of cardiovascular medicine. Conversely, inhibition of the action of key regulators of angiogenesis, such as VEGF, constitutes a promising approach for the treatment of solid tumors and intraocular neovascular syndromes. These concepts are being tested now in clinical trials.

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