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Nat Genet. 1999 Dec;23(4):397-404.

Population choice in mapping genes for complex diseases.

Author information

  • 1MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, UK. alan.wright@hgu.mrc.ac.uk


The difficulty of identifying susceptibility genes for common diseases has polarized geneticists' views on what disease models are appropriate and how best to proceed once high-density genome maps become available. Different disease models have different implications for using linkage or linkage-disequilibrium-based approaches for mapping complex disease genes. We argue that the choice of study population is a critical factor when designing a study, and that genetically simplified isolates are more useful than diverse continental populations under most assumptions.

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