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Ann Intern Med. 1999 Nov 16;131(10):752-5.

Influence of the vitamin D receptor gene polymorphism on bone loss in men after liver transplantation.

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  • 1Ciutat Sanit├ária i Universit├ária de Bellvitge, Hospital Princeps d'Espanya, Barcelona, Spain.

Abstract

BACKGROUND:

Bone loss is a frequent complication after liver transplantation.

OBJECTIVE:

To investigate whether vitamin D receptor gene polymorphism influences bone loss in men after liver transplantation.

DESIGN:

Prospective cohort study.

SETTING:

University hospital.

PATIENTS:

55 male candidates for liver transplantation.

MEASUREMENTS:

Lumbar spine bone mineral density was measured before and 3, 6, 12, and 24 months after liver transplantation. Vitamin D receptor genotype was determined by restriction endonuclease Bsml.

RESULTS:

Vitamin D receptor genotypes were significantly associated with post-transplantation changes in bone mineral density (P = 0.028). Within 3 months after transplantation, patients with the genotypes Bb or BB showed a vertebral bone loss substantially greater than that in patients with the bb genotype (between-group difference in the percentage change with respect to baseline bone mineral density, 3.7% [95% CI, 0.6% to 6.9%1). In 3 to 24 months after transplantation, bone mineral density increased steadily in the three allelic groups.

CONCLUSIONS:

Vitamin D receptor gene polymorphism influences bone loss after liver transplantation. Patients with the bb genotype are, to some extent, protected against post-transplantation bone loss.

PMID:
10577298
[PubMed - indexed for MEDLINE]
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