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Drugs. 1999;58 Suppl 1:71-3; discussion 75-82.

Prevention of type 2 diabetes: role of metformin.

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  • 1National Institute of Health and Medical Research (INSERM) Unit 21, Villejuif, France. charles@vjf.inserm.fr

Abstract

Metformin lowers moderate (nondiabetic) fasting hyperglycaemia in individuals at risk for type 2 diabetes without causing hypoglycaemia. In addition, it has demonstrated favourable action on several cardiovascular risk factors that are often present in these individuals: it favours the maintenance of diet-induced weight loss and its associated improvement in fibrinolysis; and it lowers plasma concentrations of fasting insulin, total and low density lipoprotein-cholesterol, free fatty acids, and of two markers of endothelial damage--tissue plasminogen activator antigen and von Willebrand factor. These effects together with the good tolerability profile of the drug position metformin as a first-line agent for the prevention of type 2 diabetes.

PMID:
10576529
[PubMed - indexed for MEDLINE]
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