Biochim Biophys Acta. 1999 Oct 18;1472(1-2):408-11.

Random nucleotide substitutions in primate nonfunctional gene for L-gulono-gamma-lactone oxidase, the missing enzyme in L-ascorbic acid biosynthesis.

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Department of Biochemistry, Wakayama Medical College, Japan.

Abstract

Humans and other primates have no functional gene for L-gulono-gamma-lactone oxidase that catalyzes the last step of L-ascorbic acid biosynthesis. The 164-nucleotide sequence of exon X of the gene was compared among human, chimpanzee, orangutan, and macaque, and it was found that nucleotide substitutions had occurred at random throughout the sequence with a single nucleotide deletion, indicating that the primate L-gulono-gamma-lactone oxidase genes are a typical example of pseudogene.

PMID:: 10572964; [PubMed - indexed for MEDLINE]

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Guinea pigs possess a highly mutated gene for L-gulono-gamma-lactone oxidase, the key enzyme for L-ascorbic acid biosynthesis missing in this species. [J Biol Chem. 1992]
Guinea pigs possess a highly mutated gene for L-gulono-gamma-lactone oxidase, the key enzyme for L-ascorbic acid biosynthesis missing in this species.
Nishikimi M, Kawai T, Yagi K. J Biol Chem. 1992 Oct 25; 267(30):21967-72.
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Occurrence in humans and guinea pigs of the gene related to their missing enzyme L-gulono-gamma-lactone oxidase.
Nishikimi M, Koshizaka T, Ozawa T, Yagi K. Arch Biochem Biophys. 1988 Dec; 267(2):842-6.
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Review [Molecular genetic study on the incapability of synthesising ascorbic acid in scurvy-prone animals].
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Random nucleotide substitutions in primate nonfunctional gene for L-gulono-gamma-lactone oxidase, the missing enzyme in L-ascorbic acid biosynthesis.
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