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J Neuropsychiatry Clin Neurosci. 1999 Fall;11(4):470-4.

An MRI study of the corpus callosum and cerebellum in mentally retarded autistic individuals.

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  • 1Department of Neuropsychiatry, Raúl Carrea Institute of Neurological Research-FLENI, Buenos Aires, Argentina.


The areas of seven subregions of the corpus callosum and three subregions of the cerebellum were examined on midsagittal magnetic resonance imaging scans of 27 low-IQ autistic individuals and 17 nonautistic individuals of comparable mental age. Autistic individuals had a significantly smaller corpus callosum (most marked in the body). No significant between-group differences were found in cerebellum areas. Results demonstrate that abnormalities of the corpus callosum reported in high-functioning autistic individuals are also present in autistic individuals with mental retardation and extend previous reports showing no evidence for a selective hypoplasia of cerebellar lobules VI-VII.

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