Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Mol Cell Biol. 1999 Dec;19(12):8526-35.

The zinc finger-associated SCAN box is a conserved oligomerization domain.

Author information

  • 1Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

Abstract

A number of Cys(2)His(2) zinc finger proteins contain a highly conserved amino-terminal motif termed the SCAN domain. This element is an 80-residue, leucine-rich region that contains three segments strongly predicted to be alpha-helices. In this report, we show that the SCAN motif functions as an oligomerization domain mediating self-association or association with other proteins bearing SCAN domains. These findings suggest that the SCAN domain plays an important role in the assembly and function of this newly defined subclass of transcriptional regulators.

PMID:
10567577
[PubMed - indexed for MEDLINE]
PMCID:
PMC84969
Free PMC Article

Images from this publication.See all images (4)Free text

FIG. 1
FIG. 2
FIG. 3
FIG. 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk