Neurology. 1999 Nov 10;53(8):1860-2.

Bilateral substantia nigra changes on MRI in a patient with encephalitis lethargica.

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Department of Neurology, National Neuroscience Institute,Republic of Singapore, Singapore.

Abstract

A 33-year-old woman admitted for meningoencephalitis had features of encephalitis lethargica develop on her third day of illness. She had ophthalmoplegia, akinetic mutism, and prominent extrapyramidal signs consisting of lip and hand tremors, cogwheel rigidity, and facial bradykinesia.

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