Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 1999 Nov 12;286(5443):1353-7.

Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.

Author information

  • 1Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Erratum in

  • Science 1999 Dec 17;286(5448):2273.

Abstract

In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus-type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4(+) T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in activated and proliferating T cells but also, surprisingly, in resting T cells. The infected proliferating cells correspond to the short-lived population that produces the bulk of HIV-1. Most of the HIV-1-infected resting T cells persisted after antiretroviral therapy. Latently and chronically infected cells that may be derived from this population pose challenges to eradicating infection and developing an effective vaccine.

PMID:
10558989
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk