Eur J Pharmacol. 1999 Oct 1;382(1):45-9.

Differential effects of psychostimulants and related agents on dopaminergic and serotonergic transporter function.

Fleckenstein AE, Haughey HM, Metzger RR, Kokoshka JM, Riddle EL, Hanson JE, Gibb JW, Hanson GR.

Source

Department of Pharmacology and Toxicology, University of Utah, 30 South 2000 East RM 201, Salt Lake City, UT, USA. fleckenstein@msscc.med.utah.edu

Abstract

High-dose administrations of amphetamine, methamphetamine, cathinone, methcathinone or methylenedioxymethamphetamine rapidly decrease dopamine and serotonin transporter function in vivo, as assessed in striatal synaptosomes obtained from drug-treated rats. In contrast, high-dose injections of fenfluramine, cocaine or methylphenidate had little or no effect on the activity of these transporters. Interestingly, the capacity of these agents to directly alter dopamine and serotonin uptake, as assessed in vitro by direct application to rat striatal synaptosomes, did not predict their potential to modulate transporter activity following in vivo administration. These findings demonstrate heretofore-unreported differences in the effects of these agents on monoamine transporter function, and a distinction between drug effects after direct application in vitro vs. administration in vivo.

PMID:: 10556503; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Methamphetamine-induced rapid and reversible changes in dopamine transporter function: an in vitro model. [J Neurosci. 2001]
Methamphetamine-induced rapid and reversible changes in dopamine transporter function: an in vitro model.
Sandoval V, Riddle EL, Ugarte YV, Hanson GR, Fleckenstein AE. J Neurosci. 2001 Feb 15; 21(4):1413-9.
The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia. [J Neurochem. 2000]
The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia.
Haughey HM, Fleckenstein AE, Metzger RR, Hanson GR. J Neurochem. 2000 Oct; 75(4):1608-17.
3-4-Methylenedioxymethamphetamine-induced acute changes in dopamine transporter function. [Eur J Pharmacol. 1998]
3-4-Methylenedioxymethamphetamine-induced acute changes in dopamine transporter function.
Metzger RR, Hanson GR, Gibb JW, Fleckenstein AE. Eur J Pharmacol. 1998 May 22; 349(2-3):205-10.
Review Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology. [World J Biol Psychiatry. 2002]
Review Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology.
Kasper S, Tauscher J, Willeit M, Stamenkovic M, Neumeister A, Küfferle B, Barnas C, Stastny J, Praschak-Rieder N, Pezawas L, et al. World J Biol Psychiatry. 2002 Jul; 3(3):133-46.
Review Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity. [Eur J Pharmacol. 2000]
Review Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity.
Fleckenstein AE, Gibb JW, Hanson GR. Eur J Pharmacol. 2000 Oct 6; 406(1):1-13.

See reviews... See all...

Cited by 13 PubMed Central articles

Review Pharmacological approaches to methamphetamine dependence: a focused review. [Br J Clin Pharmacol. 2010]
Review Pharmacological approaches to methamphetamine dependence: a focused review.
Karila L, Weinstein A, Aubin HJ, Benyamina A, Reynaud M, Batki SL. Br J Clin Pharmacol. 2010 Jun; 69(6):578-92.
Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter. [ACS Chem Neurosci. 2010]
Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter.
Makos MA, Han KA, Heien ML, Ewing AG. ACS Chem Neurosci. 2010 Jan 20; 1(1):74-83.
The SPECT tracer [123I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men. [Eur J Nucl Med Mol Imaging. 2010]
The SPECT tracer [123I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men.
van de Giessen E, Booij J. Eur J Nucl Med Mol Imaging. 2010 Aug; 37(8):1507-11. Epub 2010 Mar 23.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Differential effects of psychostimulants and related agents on dopaminergic and ...
Differential effects of psychostimulants and related agents on dopaminergic and serotonergic transporter function.
Eur J Pharmacol. 1999 Oct 1 ;382(1):45-9.

PubMed
Paraffin immunohistochemistry as an adjunct to hematopathology.
Paraffin immunohistochemistry as an adjunct to hematopathology.
Ann Diagn Pathol. 1999 Oct ;3(5):318-27.

PubMed
Severity of phenotype in cystinosis varies with mutations in the CTNS gene: pred...
Severity of phenotype in cystinosis varies with mutations in the CTNS gene: predicted effect on the model of cystinosin.
Hum Mol Genet. 1999 Dec ;8(13):2507-14.

PubMed
Molecular characterization of 11q deletions points to a pathogenic role of the A...
Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma.
Blood. 1999 Nov 1 ;94(9):3262-4.

PubMed
A randomized clinical trial of alpha(1)-antitrypsin augmentation therapy.
A randomized clinical trial of alpha(1)-antitrypsin augmentation therapy.
Am J Respir Crit Care Med. 1999 Nov ;160(5 Pt 1):1468-72.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: