Blood. 1999 Nov 1;94(9):3262-4.

Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma.

Stilgenbauer S, Winkler D, Ott G, Schaffner C, Leupolt E, Bentz M, Möller P, Müller-Hermelink HK, James MR, Lichter P, Döhner H.

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Department of Internal Medicine III, University of Ulm, Ulm, Germany.

Abstract

Deletions involving the long arm of chromosome 11 (11q) have been recently found as recurrent chromosome aberrations in mantle cell lymphoma (MCL). In the current study, the incidence and molecular extent of 11q deletions were analyzed in a series of 81 MCL by fluorescence in situ hybridization with probes from a contiguous set of yeast artificial chromosomes (YACs). Loss of chromosome 11 material was observed in 37 of 81 cases (46%). The minimally deleted segment comprised YAC 801e11 containing the ATM gene. To further narrow the minimal region of loss, P1-derived artificial chromosomes mapping to the critical region were isolated and used as probes in cases without aberrations detectable with YACs. This allowed the identification of an ATM deletion that was beyond the resolution of YAC probes. The identification of a minimally deleted segment affecting ATM suggests a pathogenic role of ATM as a tumor suppressor gene in MCL.

PMID:: 10556216; [PubMed - indexed for MEDLINE]

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The ATM gene in the pathogenesis of mantle-cell lymphoma. [Ann Oncol. 2000]
The ATM gene in the pathogenesis of mantle-cell lymphoma.
Stilgenbauer S, Schaffner C, Winkler D, Ott G, Leupolt E, Bentz M, Möller P, Müller-Hermelink HK, James MR, Lichter P, et al. Ann Oncol. 2000; 11 Suppl 1:127-30.
Mantle cell lymphoma is characterized by inactivation of the ATM gene. [Proc Natl Acad Sci U S A. 2000]
Mantle cell lymphoma is characterized by inactivation of the ATM gene.
Schaffner C, Idler I, Stilgenbauer S, Döhner H, Lichter P. Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6):2773-8.
Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.3-923.1 in lymphoproliferative disorders. [Proc Natl Acad Sci U S A. 1996]
Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.3-923.1 in lymphoproliferative disorders.
Stilgenbauer S, Liebisch P, James MR, Schröder M, Schlegelberger B, Fischer K, Bentz M, Lichter P, Döhner H. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11837-41.
Review 11q deletions in hematological malignancies. [Leuk Lymphoma. 2001]
Review 11q deletions in hematological malignancies.
Monni O, Knuutila S. Leuk Lymphoma. 2001 Jan; 40(3-4):259-66.
Review Absence of ATM deletions in 16 cases of splenic marginal-zone B-cell lymphoma (SMZBCL). [Haematologica. 2003]
Review Absence of ATM deletions in 16 cases of splenic marginal-zone B-cell lymphoma (SMZBCL).
Salido M, Astier L, Puigdecanet E, Espinet B, Florensa L, Solé F. Haematologica. 2003 Nov; 88(11):ELT33.

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